Hormones and Fat Distribution: Does Testosterone Therapy Help Older Women?

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The redistribution of fat is not merely a cosmetic concern. Visceral adipose tissue releases high volumes of free fatty acids directly into the portal vein. The liver absorbs this steady lipid influx, which disrupts hepatic clearance of insulin and accelerates de novo lipogenesis.

The end result is progressive insulin resistance, elevated fasting blood glucose, and dyslipidemia. Postmenopausal women experience a pronounced surge in small, dense LDL particles alongside reduced high-density lipoprotein levels. By mobilizing these central lipid pockets, targeted testosterone therapy restores hepatic insulin signaling. Clinical trial participants demonstrated meaningful reductions in systemic triglycerides and improvements in vascular endothelial elasticity, directly attenuating primary drivers of atherosclerotic disease.