How to Administer Wegovy at Home: the Complete Step-by-Step Injection Site Guide
Mechanical errors cause the vast majority of injection site reactions. The standard single-dose autoinjector pen features a concealed, pre-attached needle that fires upon firm downward pressure. Implementing a rigorous routine prevents wasted medication and subcutaneous tissue trauma.
- Temperature Moderation: Injecting semaglutide straight from the refrigerator stings significantly. Pull your pen from cold storage 15 to 30 minutes prior to use, allowing the solution to reach room temperature (between 59°F and 86°F). Do not expose the pen to direct heat or sunlight.
- Inspection: Check the viewing window. The liquid must appear completely clear and colorless. If particles or cloudiness appear, discard the device.
- Skin Preparation: Swab the target surface thoroughly with a 70% isopropyl alcohol pad. Let the skin air-dry completely for 10 to 15 seconds. Injecting through wet alcohol carries the solvent beneath the skin, causing sharp, immediate stinging.
- Positioning and Angle: Hold the autoinjector at a strict 90-degree angle perpendicular to the clean skin surface. Do not pinch the skin if you are using an autoinjector, as pinching alters the built-in depth guard mechanism; simply press down against flat, taut skin. (If drawing manually from Wegovy vials with an ultra-fine insulin syringe, pinching a fatty fold remains recommended).
- The 10-Second Rule: Press the pen firmly downward until the click mechanism triggers. You will hear an initial click indicating the injection has begun, followed by a second click several seconds later. Continue holding the pen firmly against your skin for a full count of 10 seconds after the second click to confirm the yellow plunger bar has completely stopped moving.
- Post-Injection Care: Lift the pen straight up. If a microscopic droplet of blood appears, press gently with a clean cotton ball or gauze. Avoid rubbing or massaging the site, which forces the medication into surrounding capillaries prematurely and increases bruising and skin irritation.
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